Activin Receptor type 1 - Fc Chimera

Activin RIA (also known as ACVR1 or ALK-2) is an activin type I receptor. The activin type I receptors transducer signals for a variety of members of the transforming growth factor (TGF) beta superfamily of ligands. This family of cytokine and hormones include activin, anti-mϋllerian hormone (AMH), bone morphogenetic proteins (BMPs) and nodal. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type II receptor, which recruits and trans-phosphorylates a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The R-SMAD then translocates to the nucleus where it functions as a transcription factor. Activin RIA is expressed in normal parenchymal cells, endothelial cells, fibrobasts and tumor-derived epithelial cells. Defects in the receptor are a cause of fibrodysplasia ossificans progressive (FOP).